Delayed cord clamping was not associated with an increased risk of hyperbilirubinaemia on the day of birth or jaundice in the first four weeks

Nisha Rana, Linda Jarawka Ranneberg, Mats Målqvist Ashish KC,Ola Andersson First published: 25 June 2019


Delayed cord clamping was not associated with an increased risk of hyperbilirubinaemia during the first day of life or risk of jaundice within four weeks compared with the early group.

Effect of early versus delayed cord clamping in neonate on heart rate, breathing and oxygen saturation during first 10 minutes of birth – randomized clinical trial

Ashish KC, Nalini Singhal, Jageshwor Gautam, Nisha Rana1 and Ola Andersson First published 30 May 2019


Spontaneously breathing babies subjected to DCC have higher oxygen saturation up to 10 min after birth compared to those who have undergone ECC. Spontaneously breathing babies with DCC have lower heart rates compared to ECC until 390 s. Spontaneously breathing babies receiving DCC have early establishment of breathing compared to ECC.

Effects of Delayed Cord Clamping on 4-Month Ferritin Levels, Brain Myelin Content, and Neurodevelopment: A Randomized Controlled Trial

Judith S. Mercer, PhD, Debra A. Erickson-Owens, PhD, Sean C.L. Deoni, PhD, Douglas C. Dean III, PhD, Jennifer Collins, BSN, Ashley B. Parker, BA, Meijia Wang, MPH, Sarah Joelson, BA, Emily N. Mercer, BA, James F. Padbury, MD, Published Dec 2018


At 4 months, infants born at term receiving DCC had greater ferritin levels and increased brain myelin in areas important for early life functional development. Endowment of iron-rich red blood cells obtained through DCC may offer a longitudinal advantage for early white matter development

Effect of delayed versus early umbilical cord clamping on neonatal outcomes and iron status at 4 months: a randomised controlled trial 

Ola Andersson,Lena Hellström-Westas, Dan Andersson, Magnus Domellöf, Published  November 2011

Conclusion –

We conclude that delayed cord clamping, in this randomised controlled trial, resulted in improved ferritin levels and reduced the prevalence of iron deficiency at 4 months of age. Delayed clamping also reduced the prevalence of neonatal anaemia at 2 days of age without increasing the rate of respiratory symptoms or need for phototherapy in this sample of 382 full term infants born in a high income country.

Delayed vs early umbilical cord clamping for preterm infants: a systematic review and meta-analysis

Conclusion –

This systematic review provides high-quality evidence that delayed clamping reduced hospital mortality, which supports current guidelines recommending delayed clamping in preterm infants. This review does not evaluate cord milking, which may also be of benefit. Analyses of individual patient data in these and other randomized controlled trials will be critically important in reliably evaluating important secondary outcomes.

Effect of Delayed Cord Clamping on Neurodevelopment at 4 Years of Age: A Randomized Clinical Trial

Ola Andersson, MD, PhDBarbro Lindquist, PhDMagnus Lindgren, PhD; et al July 2015

Conclusion –

Delaying CC for 3 minutes after delivery resulted in similar overall neurodevelopment and behavior among 4-year-old children compared with early CC. However, we did find higher scores for parent-reported prosocial behavior as well as personal-social and fine-motor development at 4 years, particularly in boys.

Implementing delayed umbilical cord clamping in Nepal—Delivery care staff’s perceptions and attitudes towards changes in practice

Nisha Rana , Olivia Brunell, Mats Målqvist   Published: June 12, 2019

Conclusion – Due to poor coherence within the health system and lack of national or institutional protocols, delivery staff has to rely on their own initiative to develop skills and are left to informal decision making, and are therefore hesitant to apply new routines. In order to change cord clamping practices to align with evidence and policies health-care staff needs to be better supported by the governance structures of the health system, with clear and approved guidelines made available and coherent training and support.

FDA puts company on notice for marketing unapproved stem cell products for treating serious conditions March 30 2019