Cord Blood Collection: confessions of a vampire-midwife Dr Rachel Reed

Archie Rigney and his mother Azure
(effective placental transfusion results in an empty white cord)

When I was a bright-eyed and bushy-tailed student midwife I was awarded with a certificate and a box of chocolates. My achievement was collecting the most ‘cord’ blood in the hospital. At that time the Local Health District was trialling a ‘cord’ blood bank. The collected blood was to be used for treating leukaemia and for research. Every woman birthing in the hospital was asked to donate ‘cord’ blood for the good cause, and many generously agreed. I was exceptionally good at collecting the blood. This post is a small attempt to repent for my sins.

‘Cord’ blood is baby’s blood

The term ‘cord blood’ is misleading. The blood collected via the umbilical cord is the baby’s blood. When adults donate blood it is collected via their arm. We don’t refer to that blood as ‘arm blood’.

During pregnancy the baby and placenta share the baby’s circulating blood. This allows the baby to receive nutrients and oxygen from the placenta. After birth the placental circulation alters, sending all of the baby’s blood into their body. You can read more about the ‘physiology of newborn transition’ in this this post. Penny Simkin provides a graphic illustration of blood re-distribution after birth in this movie:

Knowledge about the short term and long term health benefits of the baby having their full blood volume at birth is now widespread (see this post for details).

Stem cells

Stem cells can self-renew (make copies of themselves) and differentiate (develop into more specialised cells). At birth babies have haematopoietic stem cells in their blood. This type of stem cell is similar to those found in bone marrow and can regenerate red blood cells and immune system cells. The likelihood is that these stem cells play an important role in repairing any damage done during birth (Dr Mercer discusses this in a podcast). They may also play a role in longer term protection from disease.

The business of collecting babies blood

Companies are targeting parents and making big money from removing and
storing their baby’s blood. Care providers are also making money from recruiting parents and collecting blood for these companies. The sales pitch is: if your baby develops a particular type of illness in the future you may be able use their
stored stem cells as treatment. These companies are increasingly sponsoring
care provider organisations and events; and buying endorsement from
obstetricians and midwives. I have even been approached to endorse their
services – clearly they had not read this post. I also get fairly regular comments
on this post from undercover company reps (I can see their email address). I am deliberately avoiding linking directly to any company websites in this post – I don’t want to send them traffic or potential customers.

My main concern with ‘cord’ blood banking is the misleading information given to parents. This misinformation raises both ethical and legal issues. There are two main areas that require further clarity: blood collection volumes and cord clamping and the effectiveness of stem cell treatments.

Blood collection volumes and cord clamping

Parents need to be informed that baby’s blood collection requires premature cord clamping, and that the blood being collected belongs in the baby’s body

Paediatric guidelines state that ‘blood draws in infants and children should not exceed 5% of the total blood volume in any 24 hour period’. A 3.6kg newborn has a blood volume of around 280mls – so the maximum blood draw would be 14mls.

This collection bag hold a significant proportion of the baby’s blood

The collection bags for ‘cord’ blood hold 250mls (35mls already taken up with anticoagulant fluid). The minimum amount of blood acceptable for collection is 45mls, and the maximum possible is 215mls. In one procedure guide it states “collect as much cord blood as possible [in bold].” Another company reports that the median volume they collect is 60mls. I wonder how many parents would consent to someone coming onto the postnatal ward and sticking a needle into their baby to collect 6 adult vials of blood. Cord blood collection is the equivalent to this… only the needle is in the umbilical cord rather than the baby.

This diagram from the British Medical Journal shows the transfer of blood volume from placenta to baby after birth

In response to publicity about the importance of ‘delayed’ cord clamping. The latest marketing ploy is to tell parents they can have both ‘delayed’ cord clamping and collect ‘cord’ blood. Some of the websites even include a page on the benefits of ‘delayed’ cord clamping. However, they define delayed as 30 seconds to 1 minute. It generally takes longer for the full blood volume to transfer (see diagram). If all of the baby’s blood has transferred into the baby – however long that takes for that individual baby – then there is minimal, if any blood left to collect. Look at the picture at the top of this post. If you can get blood out of that cord you deserve a certificate and chocolates! At least one website acknowledges this, and states that the risk of ‘delayed’ cord clamping is “reducing the volume of a cord blood collection such that it cannot be banked…”. Note that public cord banks require larger volumes of blood than private at present.

In contrast one company refers specifically to ‘optimal’ cord clamping ie. waiting until the cord is white. They suggest that their company can effectively process 10-20mls of ‘cord blood’. I’d like to see evidence of that eg. photos or a movie of collection from a white cord. And, further information about the effectiveness of a small sample, as most other companies state that effective processing for storage is determined by the size of the sample.

The effectiveness of stem cell treatments

Parents need to be informed about the lack of evidence regarding the usefulness of cord blood for future treatment of their baby

There is currently no research evidence demonstrating the effectiveness of ‘cord’ blood stem cells (haematopoietic) in the treatment of disease or disability. Many company websites hint at this by using the terms ‘potential’ or ‘may’ or ‘future’ or ‘hope to’. Sites also claim that ‘cord’ blood stem cells are being used to treat ’80 diseases’ – with no mention of whether those treatments are effective or not. Some sites refer to the treatments as ‘alternative’ ie. not being used in mainstream medicine. However, others include claims of successful treatment, citing case studies or anecdotal news articles (often about stem cells in general rather than ‘cord’ blood specifically). In addition, all of the research (I can find) is being conducted on ‘public’ stem cells ie. used to treat ‘strangers’ rather than the baby who donated, or their family.

I was recently in correspondence with a representative of a cord blood company and asked for some research evidence to support his claims of successful treatments. He sent me a collection of unreferenced statements (marketing) on the company website and two feasibility studies. Feasibility studies are carried out to demonstrate that a treatment is ‘safe’, and a study is possible… they do not test the effectiveness of a treatment. I pointed this out and have not heard back. Whilst there may be a number of trials underway with ‘public’ donations, I am yet to see any actual results relating ‘cord’ blood stem cells and treatments. Send me any you may have (research articles only please).

The European Commission released a press statement about this situation stating:

“If commercial cord blood banks are allowed, appropriate information should be given to the consumers willing to use their services, including the fact that the likelihood that the sample may be used to treat one’s child is currently negligible, that the future therapeutic possibilities are of a very hypothetical nature and that up until now there is no indication that the present research will lead to specific therapeutic application of one’s own cord blood cells. Therefore, information has to be particularly explicit that the auto conservation has little value in the current state of scientific knowledge. This information should be made clear on all media, including Internet, and in any contracts linking commercial banks to their customers.”

Many companies also offer umbilical cord tissue collection as an alternative, or in addition, to ‘cord’ blood collection. Umbilical cord tissue contains mesenchymal stem cells and can be collected alongside optimal cord clamping. However, there is no evidence that this type of stem cell offers effective treatments either.

Summary

I am not suggesting that baby blood banking shouldn’t be an available option. All I am suggesting is that parents need adequate information before they make a decision to remove a significant amount of their baby’s blood volume. They need to be able to weigh up the definite benefits of full blood volume at birth vs a possible treatment for an unlikely future illness. Cord blood is baby’s blood. Parents also need know if their care provider will benefit financially from persuading them to collect and bank blood.

PS: I no longer participate in stealing babies blood. We live and learn.

Further information

Private cord blood collection and cerebral palsy – is there a connection

Is it worth storing your baby’s cord blood? – youtube